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Pojmovi o lijekovima za JIA

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 PostPoslano: 29-01-2009 16:03  Citiraj (i odgovori)  
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Pridružen: 18-06-2008 14:05
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1. linija lijekova (NSAID-NESTEROIDNI PROTUUPALNI LIJEKOVI)

- "Movalis" genericki Meloxicam
http://www.belupo.hr/Default.aspx?sid=2 ... onOTC=true
- "Dalsy" generički Ibuprofen
http://www.belupo.hr/Default.aspx?sid=4 ... table.ascx
- "Indometacin" genericki Indometacin
http://www.belupo.cz/Default.aspx?sid=1 ... onOTC=true
- "Nalgesin" generički Naproxen
http://www.tegobe.com/vademecumi/krka/nalgesin.html

2. linija lijekova (DMARD-LIJEKOVI KOJI MODIFICIRAJU TIJEK BOLESTI )
daju se dodatno na prvu liniju lijekova

- generički Metotrexate skraceno MTX
daje se u tabletama ili potkozno
http://www.plivazdravlje.hr/pda/?sectio ... u2=&id=170
http://www.jrheum.com/abstracts/editorials/990827.html
- "Arava" genericki Leflunomide
http://www.rheumatology.org/public/fact ... nomide.pdf
http://www.arava-lawyer.com/arava_links.html
http://www.fda.gov/cder/foi/label/2005/ ... 015lbl.pdf
http://www.arava.com/hcp/default.aspx
-"Imuran" generički Azathioprine
http://en.wikipedia.org/wiki/Azathioprine
http://www.gsk.com.au/resources.ashx/pr ... ablets.pdf
http://www.gsk.com.au/resources.ashx/pr ... ection.pdf

3. linija lijekova (DMARD Anti-TNF.. BIOLOŠKI LIJEKOVI)
daju se dodatno na prvu i drugu liniju lijekova

- "REMICADE" genericki Infliximab
kimericno misje-humano protutijelo, daje se infuzijom svaka 2 mjeseca
http://www.remicade.com/remicade/global/index.html
- "Humira" genericki Adalimumab
humano monoklonsko protutijelo, daje se potkozno svaka 2 tjedna
http://www.humira.com/
http://www.pcpoh.bham.ac.uk/publichealt ... imumab.pdf
- "Enbrel" genericki Etanercept
potpuni humani solubilni TNF receptor, daje se potkozno jednom ili dva puta tjedno
http://www.enbrel.com/
http://www.keele.ac.uk/schools/pharm/MT ... CEPTRA.PDF

- ORENCIA(R) (abatacept)
http://www.prnewswire.com/cgi-bin/stori ... 045&EDATE=

Glukokortikoidi

Glukokortikoidi su lijekovi iz grupe steroidnih hormona sa snažnim protuupalnim i imunosupresivnim djelovanjem. Koriste se kao dopuna temeljnim lijekovima na početku liječenja. Primjenjuju se u težim formama bolesti sa zahvaćanjem unutarnjih organa i kao trajna terapija. Mogu se primijeniti u formi injekcija u zglobove

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Anita Moorjani "Ponovno rodjena"


Zadnja izmjena: kate; 14-02-2009 23:24; ukupno mijenjano 13 put/a.

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 PostPoslano: 30-01-2009 21:09  Citiraj (i odgovori)  
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Pridružen: 18-06-2008 14:05
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Pitanje o ARAVI
http://www.cybermed.hr/index.php/pbl/po ... ijom/arava

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 30-01-2009 23:40  Citiraj (i odgovori)  
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MTX ili ARAVA što je bolje?
http://www.webmd.com/rheumatoid-arthrit ... uvenile-ra
https://content.nejm.org/cgi/reprint/35 ... pdf?ck=nck

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 03-02-2009 13:51  Citiraj (i odgovori)  
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Folna kiselina

Prilikom ljecenja MTX-om koji je antagonist folne kiseline, mora se nadomjestiti folna kiselina suplementima tipa Folacin koji smanjuju nuspojeve MTX-a, te nadoknadjuju folnu kiselinu.


o folnoj kiselini opcenito
http://www.coolinarika.com/clanak/folna-kiselina

http://www.ncbi.nlm.nih.gov/books/bv.fc ... er.a682591

Efficacy of folinic acid in reducing methotrexate toxicity in juvenile idiopathic arthritis
http://www.clinexprheumatol.org/pdf/vol ... avelli.pdf

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid

http://www.ncbi.nlm.nih.gov/pubmed/1079 ... rom=pubmed

http://www.ncbi.nlm.nih.gov/pubmed/9517 ... rom=pubmed


Leucovorin
http://www.ncbi.nlm.nih.gov/books/bv.fc ... er.a682336

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 05-02-2009 21:13  Citiraj (i odgovori)  
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Is there a consensus for the dosage of folic acid to be given as local rheumatalogists vary from 5mg daily to 10mg weekly? Is there any indication for taking the weekly amount 1 day prior to taking methotrexate?

http://www.attract.wales.nhs.uk/questio ... on_id=2288

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 05-02-2009 23:34  Citiraj (i odgovori)  
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Kortikosteroidi

Corticosteroids for juvenile rheumatoid arthritis
http://www.questdiagnostics.com/kbase/t ... detail.htm

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 10-02-2009 14:51  Citiraj (i odgovori)  
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Humira- Adalimumab in the therapy of uveitis in childhood.

Biester S, Deuter C, Michels H, Haefner R, Kuemmerle-Deschner J, Doycheva D, Zierhut M.
Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany.

PURPOSE: Chronic anterior uveitis in children often takes a serious course. Despite various immunosuppressive drugs some children do not respond sufficiently and there is a high risk of them becoming seriously disabled. Anti-TNF alpha therapy has been shown by our group and others to be mostly ineffective (Etanercept) or partly effective (Infliximab) with the risk of anaphylactic reactions. Here we report on 18 young patients treated with Adalimumab (Humira), a complete humanised anti-TNF alpha antibody. METHODS: We retrospectively analysed 18 patients, who were treated with Adalimumab (20-40 mg, every 2 weeks, when ineffective every week); 17 had juvenile idiopathic arthritis, one was without detectable underlying disease. The age at onset of arthritis varied from 0.5-15 years and for uveitis from 2-19 years. Patients were included when the previous anti-inflammatory therapy had been ineffective. It consisted of systemic steroids (n = 18), Cyclosporin A (n = 18), Methotrexate (n = 18), Azathioprine (n = 12), Mycophenolate mofetil (n = 4), Cyclophosphamide (n = 2), Leflunomide (n = 3), Etanercept (n = 8) and Infliximab (n = 5). The grading for uveitis was: (a) effective: no relapse or more than two relapses less than before treatment, (b) mild: one relapse less than before treatment, (c) no response: no change in relapse rate and (d) worsening: more relapses under treatment than before. The grading for arthritis (depending on the clinical findings), using three out of six parameters of the ACR PED Criteria, was: effective, mild, no response, worsening. RESULTS: For arthritis (n = 16) the response to Adalimumab was effective in 10 of 16 patients, mild in three patients, three did not respond. For uveitis (n = 18) Adalimumab was effective in 16, mild in one child, and one patient did not show any effect. After a very good response initially a shorter application time had to be used to maintain the good anti-inflammatory effect in one child. Additional immunosuppressive treatment was used in seven of the effectively treated children. Due to elevation of liver enzymes in one patient, who also took MTX, Adalimumab had to be discontinued. No anaphylactic reactions or increased frequency of infections since start of Adalimumab treatment was reported. CONCLUSIONS: For our group of children with long lasting disease our results show that Adalimumab was effective or mildly effective against the arthritis in 81%, but in uveitis in 88%. While these results regarding arthritis are comparable with other TNF-alpha blocking drugs (Etanercept), Adalimumab seems to be much more effective against uveitis than Etanercept. Anaphylactic reactions, found in a previous study from our group after Infliximab treatment, were not seen with Adalimumab. The necessary dosage and the treatment period, which probably have to be defined individually for each patient, remain unclear


http://www.ncbi.nlm.nih.gov/pubmed/17035274
http://www.cornellpediatrics.org/bm~doc ... veitis.pdf

Adalimumab and severe uveitis in juvenile idiopathic arthritis (JIA)therapy
http://www.ped-rheum.com/content/pdf/15 ... S1-P76.pdf

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Anita Moorjani "Ponovno rodjena"


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 PostPoslano: 27-11-2012 20:39  Citiraj (i odgovori)  
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Pridružen: 03-12-2008 14:23
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Vjrovatno ste već pročitali ali nema veze,ima gore više sve o Aravi i ostalim lijekovima



http://www.almp.hr/upl/lijekovi/PIL/UP- ... 02-174.pdf

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dobar dan... ja sam stara Dragica ...samo igram za tim ozdravljenje pa otud broj 1:-)


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